BIOinformaatika kodutöö 5 (0)

Informaatika - Bioinformaatika

5 VÄGA HEA

Bioinformaatika 5

Andmebaasid (KEGG, NCBI, RCSB), järjestuste (SMS, BioEdit) ja struktuuride (SPdbV) analüüs

KEGG-i kasutamine ( http://www.genome.jp/

Leida liikide Escherichia coli K12 MG1655, Drosophila melanogaster ja Homo sapiens glükolüüsi rajad ning ensüümid aldolaas ja püruvaatkinaas.
Escherichia coli glükolüüsi rada:
http://www.kegg.com/dbget-bin/get_pathway?org_name=eco&mapno=00010
Drosophila glükolüüsi rada:
http://www.kegg.com/dbget-bin/get_pathway?org_name=dme&mapno=00010
Homo sapiens glükolüüsi rada:
http://www.kegg.com/dbget-bin/get_pathway?org_name=hsa&mapno=00010
aldodaas:
http://www.kegg.com/dbget-bin/www_bget?enzyme+4.1.2.13
püruvaatkinees:
http://www.kegg.com/dbget-bin/www_bget?enzyme+2.7.1.40

Leida vastavad geenid – KEGG-i entry numbrid , geeni nimed, nukleotiidsed järjestused ning asukohad geenikaardil.
Aldolaas :
Escherichia coli K12 MG1655:
http://www.kegg.com/dbget-bin/www_bget?eco+b2097
Drosophila melanogaster:
http://www.kegg.com/dbget-bin/www_bget?dme+Dmel_CG6058
Homo sapiens:
http://www.kegg.com/dbget-bin/www_bget?hsa+226
Püruvaatkinaas :
Escherichia coli K12 MG1655:
http://www.kegg.com/dbget-bin/www_bget?eco+b1676
Drosophila melanogaster:
http://www.kegg.com/dbget-bin/www_bget?dme+Dmel_CG7069
Homo sapiens:
http://www.kegg.com/dbget-bin/www_bget?hsa+5313

Leida vastavate geenidega seotud ensüümide klassid , aminohappelised järjestused, EC number.
Aldolaas:
EC 4.1.2.13
Class
Lyases
Carbon-carbon lyases
Aldehyde-lyases
Escherichia coli K12 MG1655:
>eco:b2097 fbaB, dhnA; fructose-bisphosphate aldolase class I [EC:4.1.2.13]; K01623 fructose-bisphosphate aldolase, class I (A)
MTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTG
RLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVS
RRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIYFGSEESRRQIE
EISAAFERAHELGMVTVLWAYLRNSAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKM
AENNGGYKAINYGYTDDRVYSKLTSENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLS
DAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKITIA
Drosophila melanogaster:
>dme:Dmel_CG6058 Ald; Aldolase [EC:4.1.2.13]; K01623 fructose-bisphosphate aldolase, class I (A)
MTTYFNYPSKELQDELREIAQKIVAPGKGILAADESGPTMGKRLQDIGVENTEDNRRAYR
QLLFSTDPKLAENISGVILFHETLYQKADDGTPFAEILKKKGIILGIKVDKGVVPLFGSE
DEVTTQGLDDLAARCAQYKKDGCDFAKWRCVLKIGKNTPSYQSILENANVLARYASICQS
QRIVPIVEPEVLPDGDHDLDRAQKVTETVLAAVYKALSDHHVYLEGTLLKPNMVTAGQSA
KKNTPEEIALATVQALRRTVPAAVTGVTFLSGGQSEEEATVNLSAINNVPLIRPWALTFS
YGRALQASVLRAWAGKKENIAAGQNELLKRAKANGEAACGNYTAGSVKGFAGKDTLHVDD
HRY
Homo sapiens:
>hsa:226 ALDOA; aldolase A, fructose-bisphosphate [EC:4.1.2.13]; K01623 fructose-bisphosphate aldolase, class I (A)
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR
QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTN
GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQ
NGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHAC
TQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTF
SYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVS
NHAY
Püruvaatkinaas:
EC 2.7.1.40
Class
Transferases
Transferring phosphorus -containing groups
Phosphotransferases with an alcohol group as acceptor
Escherichia coli K12 MG1655:
>eco:b1676 pykF; pyruvate kinase [EC:2.7.1.40]; K00873 pyruvate kinase (A)
MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKT
AAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVG
NTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIF
GCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGI
MVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVAN
AILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNRKLRITEAVCR
GAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLV
KEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL
Drosophila melanogaster:
>dme:Dmel_CG7069 CG7069 [EC:2.7.1.40]; K00873 pyruvate kinase (A)
MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGN
DRAEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKE
SKGDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRD
ANALKEIRQVLGPAGACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVP
LAQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAK
GKYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHISAVTTAIAEAATVGQAR
AIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFRR
IMQSGLKLMGKMDILEPGQKGSVVLVNAMSAEKITFRLFTIRQQTKEERDQDERCRKLAL
EQSCKERAEKEECRKLQQAEECQKQKLAKKCKQFEEKQKVCPKKNDTPKNDCPKKDCPKK
ECPKQDDEISKCRQMQEAEAEERKCKEEFEQMCKLAEEKRKEAEKCRKADEERRKEEAEK
CRKLEEDRKCKLAEEKKRNEEELKIIEAEVAKLEAAEKAKRLKEEEKKKEELMKCKQRNE
AKKKREEAERCKRKERERELAEMENKWKQVAEKRKRKKAAEMCRKIEDAKEKAAAESADK
ILKAVCEKLKQSLSDPDKSKKGKK
Homo sapiens:
>hsa:5313 PKLR; pyruvate kinase, liver and RBC [EC:2.7.1.40]; K00873 pyruvate kinase (A)
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS

Kirjeldada nende ensüümide poolt katalüüsitavaid reaktsioone ja nendes osalevaid molekule.
Aldolaas:
http://www.kegg.com/dbget-bin/www_bget?rn+R01068
Püruvaatkinaas:
http://www.kegg.com/dbget-bin/www_bget?rn+R00200

Leida antud geenide/ensüümidega seotud haiguste kirjeldused (MIM) ja kirjanduse viited bibliograafilistest andmebaasidest.
Aldolaas:
Disease
Aldolase A, fructose-bisphosphatase
http://www.kegg.com/dbget-bin/www_bget?omim+103850
Aldolase C, fructose-bisphosphatase
http://www.kegg.com/dbget-bin/www_bget?omim+103870
Aldolase B, fructose-bisphosphatase
http://www.kegg.com/dbget-bin/www_bget?omim+229600
Reference
1
Horecker, B.L., Tsolas, O. and Lai, C.Y. Aldolases, in Boyer, P.D.
(Ed.), The Enzymes, 3rd edn., vol. 7, Academic Press, New York ,
1972, pp. 213-258.
2 http://www.kegg.com/dbget-bin/www_bget?medline+2649077
Alefounder PR, Baldwin SA, Perham RN, Short NJ.
Cloning, sequence analysis and over-expression of the gene for the
class II fructose 1,6-bisphosphate aldolase of Escherichia coli.
Biochem. J. 257 (1989) 529-34.
Püruvaatkinaas:
Disease
Pyruvate kinase-3
http://www.kegg.com/dbget-bin/www_bget?omim+179050
Pyruvate kinase, liver and RBC type
http://www.kegg.com/dbget-bin/www_bget?omim+609712
Reference
1
Boyer, P.D. Pyruvate kinase. In: Boyer, P.D., Lardy, H. and Myrback,
K. (Eds.), The Enzymes, 2nd edn., vol. 6, Academic Press, New York,
1962, pp. 95-113.
2
Kornberg, A. and Pricer, W.E. Enzymatic phosphorylation of adenosine
and 2,6-diaminopurine riboside. J. Biol. Chem. 193 (1951) 481-495.
3
Kubowitz, F. and Ott, P. Isolierung von Garungsfermenten aus
menschlichen Muskeln. Biochem. Z. 317 (1944) 193-203.
4
Strominger, J.L. Enzymatic synthesis of guanosine and cytidine
triphosphates: a note on the nucleotide specificity of the pyruvate
phosphokinase reaction. Biochim. Biophys. Acta 16 (1955) 616-618.
5
Tietz, A. and Ochoa, S. "Fluorokinase" and pyruvic kinase. Arch .
Biochem. Biophys. 78 (1958) 477-493.

SMS 2 (Sequence Manipulation Suite , http://bioinformatics.org/sms2/ ) kasutamine (vähemalt 10 manipulatsiooni ):

Salvestada leitud E.coli ja H.sapiensi geenide ja valkude järjestused arvutisse FASTA formaadis failidena.

Failiformaatide konverteerimine (FASTA formaadis nukleotiidsete ja aminohappeliste järjestuste väljasõelumine GenBanki jt formaadist, aminohapete järjestuse muutmine 1-tähelistest koodidest 3-tähelisteks ja vastupidi, valkude ja DNA järjestuste filtreerimine, järjestuse teatud piirkondade väljavõtmine).

Koodonite kasutussageduse uurimine , mustrite otsimine järjestuses, nukleotiidide ja aminohapete sisaldused järjestustes, ORF-de leidmine, PCR produktide otsimine, valgu isoelektrilise punkti arvutamine, valgu molekulmassi arvutamine, restriktsioonisaitide kindlakstegemine , (de)transleerimine, restriktsioonikaartide tegemine, translatsioonikaardid, praimerikaardid.
Aldolaasi E. coli nukleotiidne järjestus:
>eco:b2097 fbaB, dhnA; fructose-bisphosphate aldolase class I [EC:4.1.2.13]; K01623 fructose-bisphosphate aldolase, class I
atgacagatattgcgcagttgcttggcaaagacgccgacaaccttttacagcaccgttgt
atgacaattccttctgaccagctttatctccccggacatgactacgtagaccgcgtaatg
attgacaataatcgcccgccagcggtgttacgtaatatgcagacgttgtacaacaccggg
cgtctggctggcacaggatatctttctattctgccggttgaccagggcgttgagcactct
gccggagcttcatttgctgctaacccgctctactttgacccgaaaaacattgttgaactg
gcgatcgaagcgggctgtaactgtgtggcgtcaacttacggcgtgctggcgtcggtatcg
cggcgttatgcgcatcgcattccattcctcgtcaaacttaatcacaacgagacgctaagt
tacccgaatacctacgatcaaacgctgtatgccagcgtggagcaggcgttcaacatgggc
gcggttgcggttggtgcgactatctattttggctcggaagagtcacgtcgccagattgaa
gaaatttctgcggcttttgaacgtgcgcacgagctgggtatggtgacagtgctgtgggcc
tatttgcgtaactccgcctttaagaaagatggcgttgattaccatgtttccgccgacctg
accggtcaggcaaaccatctggcggcaaccatcggtgcagatatcgtcaaacaaaaaatg
gcggaaaataacggcggctataaagcaattaattacggttacaccgacgatcgtgtttac
agcaaattgaccagcgaaaacccgattgatctggtgcgttatcagttagctaactgctat
atgggtcgggctgggttgataaactccggcggtgctgcgggcggtgaaactgacctcagc
gatgcagtgcgtactgcggttatcaacaaacgcgcaggcggaatggggctgattcttgga
cgtaaagcgttcaagaaatcgatggctgacggcgtgaaactgattaacgccgtgcaggac
gtttatctcgatagcaaaattactatcgcctga

10 manipulatsiooni aldolaasi E. coli nukleotiidse järjestusega:

Filter DNA
> filtered DNA sequence consisting of 1075 bases .
canActataacaCctataacaNatgacagatattgcgcagttgcttggcaaagacgccga
caaccttttacagcaccgttgtatgacaattccttctgaccagctttatctccccggaca
tgactacgtagaccgcgtaatgattgacaataatcgcccgccagcggtgttacgtaatat
gcagacgttgtacaacaccgggcgtctggctggcacaggatatctttctattctgccggt
tgaccagggcgttgagcactctgccggagcttcatttgctgctaacccgctctactttga
cccgaaaaacattgttgaactggcgatcgaagcgggctgtaactgtgtggcgtcaactta
cggcgtgctggcgtcggtatcgcggcgttatgcgcatcgcattccattcctcgtcaaact
taatcacaacgagacgctaagttacccgaatacctacgatcaaacgctgtatgccagcgt
ggagcaggcgttcaacatgggcgcggttgcggttggtgcgactatctattttggctcgga
agagtcacgtcgccagattgaagaaatttctgcggcttttgaacgtgcgcacgagctggg
tatggtgacagtgctgtgggcctatttgcgtaactccgcctttaagaaagatggcgttga
ttaccatgtttccgccgacctgaccggtcaggcaaaccatctggcggcaaccatcggtgc
agatatcgtcaaacaaaaaatggcggaaaataacggcggctataaagcaattaattacgg
ttacaccgacgatcgtgtttacagcaaattgaccagcgaaaacccgattgatctggtgcg
ttatcagttagctaactgctatatgggtcgggctgggttgataaactccggcggtgctgc
gggcggtgaaactgacctcagcgatgcagtgcgtactgcggttatcaacaaacgcgcagg
cggaatggggctgattcttggacgtaaagcgttcaagaaatcgatggctgacggcgtgaa
actgattaacgccgtgcaggacgtttatctcgatagcaaaattactatcgcctga

CpG Islands
CpG Islands results
Results for 1053 residue sequence "eco:b2097 fbaB, dhnA; fructose-bisphosphate aldolase class I [EC:4.1.2.13]; K01623 fructose-bisphosphate aldolase, class I (N)" starting "atgacagata"
CpG island detected in region 3 to 202 (Obs/Exp = 1.18 and %GC = 50.50)
CpG island detected in region 18 to 217 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 21 to 220 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 24 to 223 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 25 to 224 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 26 to 225 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 27 to 226 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 28 to 227 (Obs/Exp = 1.19 and %GC = 50.50)
CpG island detected in region 29 to 228 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 30 to 229 (Obs/Exp = 1.22 and %GC = 51.50)
CpG island detected in region 31 to 230 (Obs/Exp = 1.22 and %GC = 51.50)
CpG island detected in region 32 to 231 (Obs/Exp = 1.24 and %GC = 51.00)
CpG island detected in region 33 to 232 (Obs/Exp = 1.22 and %GC = 51.50)
CpG island detected in region 34 to 233 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 35 to 234 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 36 to 235 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 37 to 236 (Obs/Exp = 1.10 and %GC = 50.50)
CpG island detected in region 38 to 237 (Obs/Exp = 1.11 and %GC = 50.50)
CpG island detected in region 39 to 238 (Obs/Exp = 1.11 and %GC = 50.50)
CpG island detected in region 40 to 239 (Obs/Exp = 1.11 and %GC = 50.50)
CpG island detected in region 41 to 240 (Obs/Exp = 1.11 and %GC = 50.50)
CpG island detected in region 42 to 241 (Obs/Exp = 1.08 and %GC = 51.00)
CpG island detected in region 43 to 242 (Obs/Exp = 1.08 and %GC = 51.00)
CpG island detected in region 44 to 243 (Obs/Exp = 1.08 and %GC = 51.00)
CpG island detected in region 45 to 244 (Obs/Exp = 1.14 and %GC = 51.50)
CpG island detected in region 46 to 245 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 47 to 246 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 48 to 247 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 49 to 248 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 50 to 249 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 51 to 250 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 52 to 251 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 53 to 252 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 54 to 253 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 55 to 254 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 56 to 255 (Obs/Exp = 1.08 and %GC = 51.00)
CpG island detected in region 57 to 256 (Obs/Exp = 1.08 and %GC = 51.00)
CpG island detected in region 58 to 257 (Obs/Exp = 1.06 and %GC = 51.50)
CpG island detected in region 59 to 258 (Obs/Exp = 1.06 and %GC = 51.50)
CpG island detected in region 60 to 259 (Obs/Exp = 1.06 and %GC = 51.50)
CpG island detected in region 61 to 260 (Obs/Exp = 1.04 and %GC = 52.00)
CpG island detected in region 62 to 261 (Obs/Exp = 1.04 and %GC = 52.00)
CpG island detected in region 63 to 262 (Obs/Exp = 1.04 and %GC = 52.00)
CpG island detected in region 64 to 263 (Obs/Exp = 1.06 and %GC = 51.50)
CpG island detected in region 65 to 264 (Obs/Exp = 1.04 and %GC = 52.00)
CpG island detected in region 66 to 265 (Obs/Exp = 1.04 and %GC = 52.00)
CpG island detected in region 67 to 266 (Obs/Exp = 1.02 and %GC = 52.50)
CpG island detected in region 68 to 267 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 69 to 268 (Obs/Exp = 1.06 and %GC = 53.50)
CpG island detected in region 70 to 269 (Obs/Exp = 1.06 and %GC = 53.50)
CpG island detected in region 71 to 270 (Obs/Exp = 1.06 and %GC = 53.50)
CpG island detected in region 72 to 271 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 73 to 272 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 74 to 273 (Obs/Exp = 1.06 and %GC = 53.50)
CpG island detected in region 75 to 274 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 76 to 275 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 77 to 276 (Obs/Exp = 1.10 and %GC = 52.50)
CpG island detected in region 78 to 277 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 79 to 278 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 80 to 279 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 81 to 280 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 82 to 281 (Obs/Exp = 1.08 and %GC = 53.00)
CpG island detected in region 83 to 282 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 84 to 283 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 85 to 284 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 86 to 285 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 87 to 286 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 88 to 287 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 89 to 288 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 90 to 289 (Obs/Exp = 1.15 and %GC = 53.00)
CpG island detected in region 91 to 290 (Obs/Exp = 1.17 and %GC = 52.50)
CpG island detected in region 92 to 291 (Obs/Exp = 1.19 and %GC = 52.00)
CpG island detected in region 93 to 292 (Obs/Exp = 1.19 and %GC = 52.00)
CpG island detected in region 94 to 293 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 95 to 294 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 96 to 295 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 97 to 296 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 98 to 297 (Obs/Exp = 1.18 and %GC = 50.50)
CpG island detected in region 99 to 298 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 100 to 299 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 101 to 300 (Obs/Exp = 1.16 and %GC = 51.00)
CpG island detected in region 102 to 301 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 103 to 302 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 104 to 303 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 105 to 304 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 106 to 305 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 107 to 306 (Obs/Exp = 1.13 and %GC = 51.50)
CpG island detected in region 108 to 307 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 109 to 308 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 110 to 309 (Obs/Exp = 1.21 and %GC = 51.50)
CpG island detected in region 111 to 310 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 112 to 311 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 113 to 312 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 114 to 313 (Obs/Exp = 1.18 and %GC = 52.00)
CpG island detected in region 115 to 314 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 116 to 315 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 117 to 316 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 118 to 317 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 119 to 318 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 120 to 319 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 121 to 320 (Obs/Exp = 1.11 and %GC = 52.00)
CpG island detected in region 122 to 321 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 123 to 322 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 124 to 323 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 125 to 324 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 126 to 325 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 127 to 326 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 128 to 327 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 129 to 328 (Obs/Exp = 1.05 and %GC = 53.50)
CpG island detected in region 130 to 329 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 131 to 330 (Obs/Exp = 1.08 and %GC = 54.50)
CpG island detected in region 132 to 331 (Obs/Exp = 1.08 and %GC = 54.50)
CpG island detected in region 133 to 332 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 134 to 333 (Obs/Exp = 1.01 and %GC = 54.50)
CpG island detected in region 135 to 334 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 136 to 335 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 137 to 336 (Obs/Exp = 1.05 and %GC = 53.50)
CpG island detected in region 138 to 337 (Obs/Exp = 1.00 and %GC = 53.00)
CpG island detected in region 139 to 338 (Obs/Exp = 1.02 and %GC = 52.50)
CpG island detected in region 140 to 339 (Obs/Exp = 1.02 and %GC = 52.50)
CpG island detected in region 141 to 340 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 142 to 341 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 143 to 342 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 144 to 343 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 145 to 344 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 146 to 345 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 147 to 346 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 148 to 347 (Obs/Exp = 1.09 and %GC = 52.50)
CpG island detected in region 149 to 348 (Obs/Exp = 1.07 and %GC = 53.00)
CpG island detected in region 150 to 349 (Obs/Exp = 1.05 and %GC = 53.50)
CpG island detected in region 151 to 350 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 152 to 351 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 153 to 352 (Obs/Exp = 1.05 and %GC = 53.50)
CpG island detected in region 154 to 353 (Obs/Exp = 1.03 and %GC = 54.00)
CpG island detected in region 155 to 354 (Obs/Exp = 1.08 and %GC = 54.50)
CpG island detected in region 156 to 355 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 157 to 356 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 158 to 357 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 159 to 358 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 160 to 359 (Obs/Exp = 1.06 and %GC = 55.00)
CpG island detected in region 161 to 360 (Obs/Exp = 1.13 and %GC = 55.00)
CpG island detected in region 162 to 361 (Obs/Exp = 1.11 and %GC = 55.50)
CpG island detected in region 163 to 362 (Obs/Exp = 1.17 and %GC = 55.50)
CpG island detected in region 164 to 363 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 165 to 364 (Obs/Exp = 1.09 and %GC = 56.00)
CpG island detected in region 166 to 365 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 167 to 366 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 168 to 367 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 169 to 368 (Obs/Exp = 1.17 and %GC = 55.50)
CpG island detected in region 170 to 369 (Obs/Exp = 1.17 and %GC = 55.50)
CpG island detected in region 171 to 370 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 172 to 371 (Obs/Exp = 1.15 and %GC = 56.00)
CpG island detected in region 173 to 372 (Obs/Exp = 1.19 and %GC = 56.50)
CpG island detected in region 174 to 373 (Obs/Exp = 1.17 and %GC = 57.00)
CpG island detected in region 175 to 374 (Obs/Exp = 1.19 and %GC = 56.50)
CpG island detected in region 176 to 375 (Obs/Exp = 1.19 and %GC = 56.50)
CpG island detected in region 177 to 376 (Obs/Exp = 1.19 and %GC = 56.50)
CpG island detected in region 178 to 377 (Obs/Exp = 1.20 and %GC = 56.50)
CpG island detected in region 179 to 378 (Obs/Exp = 1.19 and %GC = 56.50)
CpG island detected in region 180 to 379 (Obs/Exp = 1.22 and %GC = 56.00)
CpG island detected in region 181 to 380 (Obs/Exp = 1.24 and %GC = 55.50)
CpG island detected in region 182 to 381 (Obs/Exp = 1.19 and %GC = 55.00)
CpG island detected in region 183 to 382 (Obs/Exp = 1.19 and %GC = 55.00)
CpG island detected in region 184 to 383 (Obs/Exp = 1.17 and %GC = 55.50)
CpG island detected in region 185 to 384 (Obs/Exp = 1.19 and %GC = 55.00)
CpG island detected in region 186 to 385 (Obs/Exp = 1.19 and %GC = 55.00)
CpG island detected in region 187 to 386 (Obs/Exp = 1.21 and %GC = 54.50)
CpG island detected in region 188 to 387 (Obs/Exp = 1.21 and %GC = 54.50)
CpG island detected in region 189 to 388 (Obs/Exp = 1.21 and %GC = 54.50)
CpG island detected in region 190 to 389 (Obs/Exp = 1.21 and %GC = 54.50)
CpG island detected in region 191 to 390 (Obs/Exp = 1.21 and %GC = 54.50)
CpG island detected in region 192 to 391 (Obs/Exp = 1.28 and %GC = 54.50)
CpG island detected in region 193 to 392 (Obs/Exp = 1.30 and %GC = 54.00)
CpG island detected in region 194 to 393 (Obs/Exp = 1.28 and %GC = 54.50)
CpG island detected in region 195 to 394 (Obs/Exp = 1.30 and %GC = 54.00)
CpG island detected in region 196 to 395 (Obs/Exp = 1.30 and %GC = 54.00)
CpG island detected in region 197 to 396 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 198 to 397 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 199 to 398 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 200 to 399 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 201 to 400 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 202 to 401 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 203 to 402 (Obs/Exp = 1.35 and %GC = 53.00)
CpG island detected in region 204 to 403 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 205 to 404 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 206 to 405 (Obs/Exp = 1.30 and %GC = 54.00)
CpG island detected in region 207 to 406 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 208 to 407 (Obs/Exp = 1.33 and %GC = 53.50)
CpG island detected in region 209 to 408 (Obs/Exp = 1.30 and %GC = 54.00)
CpG island detected in region 210 to 409 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 211 to 410 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 212 to 411 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 213 to 412 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 214 to 413 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 215 to 414 (Obs/Exp = 1.41 and %GC = 54.50)
CpG island detected in region 216 to 415 (Obs/Exp = 1.35 and %GC = 54.50)
CpG island detected in region 217 to 416 (Obs/Exp = 1.37 and %GC = 54.00)
CpG island detected in region 218 to 417 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 219 to 418 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 220 to 419 (Obs/Exp = 1.37 and %GC = 54.00)
CpG island detected in region 221 to 420 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 222 to 421 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 223 to 422 (Obs/Exp = 1.42 and %GC = 53.00)
CpG island detected in region 224 to 423 (Obs/Exp = 1.42 and %GC = 53.00)
CpG island detected in region 225 to 424 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 226 to 425 (Obs/Exp = 1.40 and %GC = 53.50)
CpG island detected in region 227 to 426 (Obs/Exp = 1.47 and %GC = 53.50)
CpG island detected in region 228 to 427 (Obs/Exp = 1.50 and %GC = 53.00)
CpG island detected in region 229 to 428 (Obs/Exp = 1.45 and %GC = 52.50)
CpG island detected in region 230 to 429 (Obs/Exp = 1.48 and %GC = 52.00)
CpG island detected in region 231 to 430 (Obs/Exp = 1.48 and %GC = 52.00)
CpG island detected in region 232 to 431 (Obs/Exp = 1.46 and %GC = 52.50)
CpG island detected in region 233 to 432 (Obs/Exp = 1.46 and %GC = 52.50)
CpG island detected in region 234 to 433 (Obs/Exp = 1.46 and %GC = 52.50)
CpG island detected in region 235 to 434 (Obs/Exp = 1.49 and %GC = 52.00)
CpG island detected in region 236 to 435 (Obs/Exp = 1.49 and %GC = 52.00)
CpG island detected in region 237 to 436 (Obs/Exp = 1.54 and %GC = 52.50)
CpG island detected in region 238 to 437 (Obs/Exp = 1.56 and %GC = 52.00)
CpG island detected in region 239 to 438 (Obs/Exp = 1.56 and %GC = 52.00)
CpG island detected in region 240 to 439 (Obs/Exp = 1.56 and %GC = 52.00)
CpG island detected in region 241 to 440 (Obs/Exp = 1.56 and %GC = 52.00)
CpG island detected in region 242 to 441 (Obs/Exp = 1.60 and %GC = 51.50)
CpG island detected in region 243 to 442 (Obs/Exp = 1.62 and %GC = 51.00)
CpG island detected in region 244 to 443 (Obs/Exp = 1.55 and %GC = 51.00)
CpG island detected in region 245 to 444 (Obs/Exp = 1.62 and %GC = 51.00)
CpG island detected in region 246 to 445 (Obs/Exp = 1.63 and %GC = 51.00)
CpG island detected in region 247 to 446 (Obs/Exp = 1.63 and %GC = 51.00)
CpG island detected in region 248 to 447 (Obs/Exp = 1.63 and %GC = 51.00)
CpG island detected in region 249 to 448 (Obs/Exp = 1.66 and %GC = 50.50)
CpG island detected in region 250 to 449 (Obs/Exp = 1.66 and %GC = 50.50)
CpG island detected in region 251 to 450 (Obs/Exp = 1.66 and %GC = 50.50)
CpG island detected in region 252 to 451 (Obs/Exp = 1.65 and %GC = 50.50)
CpG island detected in region 253 to 452 (Obs/Exp = 1.62 and %GC = 51.00)
CpG island detected in region 254 to 453 (Obs/Exp = 1.60 and %GC = 51.50)
CpG island detected in region 255 to 454 (Obs/Exp = 1.60 and %GC = 51.50)
CpG island detected in region 256 to 455 (Obs/Exp = 1.56 and %GC = 52.00)
CpG island detected in region 257 to 456 (Obs/Exp = 1.57 and %GC = 52.00)
CpG island detected in region 258 to 457 (Obs/Exp = 1.64 and %GC = 52.00)
CpG island detected in region 259 to 458 (Obs/Exp = 1.64 and %GC = 52.00)
CpG island detected in region 260 to 459 (Obs/Exp = 1.64 and %GC = 52.00)
CpG island detected in region 261 to 460 (Obs/Exp = 1.63 and %GC = 52.00)
CpG island detected in region 262 to 461 (Obs/Exp = 1.63 and %GC = 52.00)
CpG island detected in region 263 to 462 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 264 to 463 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 265 to 464 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 266 to 465 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 267 to 466 (Obs/Exp = 1.52 and %GC = 52.50)
CpG island detected in region 268 to 467 (Obs/Exp = 1.53 and %GC = 52.50)
CpG island detected in region 269 to 468 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 270 to 469 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 271 to 470 (Obs/Exp = 1.63 and %GC = 52.00)
CpG island detected in region 272 to 471 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 273 to 472 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 274 to 473 (Obs/Exp = 1.63 and %GC = 52.00)
CpG island detected in region 275 to 474 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 276 to 475 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 277 to 476 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 278 to 477 (Obs/Exp = 1.60 and %GC = 52.50)
CpG island detected in region 279 to 478 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 280 to 479 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 281 to 480 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 282 to 481 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 283 to 482 (Obs/Exp = 1.57 and %GC = 53.00)
CpG island detected in region 284 to 483 (Obs/Exp = 1.61 and %GC = 53.50)
CpG island detected in region 285 to 484 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 286 to 485 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 287 to 486 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 288 to 487 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 289 to 488 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 290 to 489 (Obs/Exp = 1.59 and %GC = 55.00)
CpG island detected in region 291 to 490 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 292 to 491 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 293 to 492 (Obs/Exp = 1.59 and %GC = 55.00)
CpG island detected in region 294 to 493 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 295 to 494 (Obs/Exp = 1.54 and %GC = 56.00)
CpG island detected in region 296 to 495 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 297 to 496 (Obs/Exp = 1.54 and %GC = 56.00)
CpG island detected in region 298 to 497 (Obs/Exp = 1.51 and %GC = 56.50)
CpG island detected in region 299 to 498 (Obs/Exp = 1.58 and %GC = 56.50)
CpG island detected in region 300 to 499 (Obs/Exp = 1.58 and %GC = 56.50)
CpG island detected in region 301 to 500 (Obs/Exp = 1.57 and %GC = 56.50)
CpG island detected in region 302 to 501 (Obs/Exp = 1.60 and %GC = 56.00)
CpG island detected in region 303 to 502 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 304 to 503 (Obs/Exp = 1.59 and %GC = 55.00)
CpG island detected in region 305 to 504 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 306 to 505 (Obs/Exp = 1.56 and %GC = 55.50)
CpG island detected in region 307 to 506 (Obs/Exp = 1.53 and %GC = 55.00)
CpG island detected in region 308 to 507 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 309 to 508 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 310 to 509 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 311 to 510 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 312 to 511 (Obs/Exp = 1.51 and %GC = 54.00)
CpG island detected in region 313 to 512 (Obs/Exp = 1.51 and %GC = 54.00)
CpG island detected in region 314 to 513 (Obs/Exp = 1.51 and %GC = 54.00)
CpG island detected in region 315 to 514 (Obs/Exp = 1.54 and %GC = 53.50)
CpG island detected in region 316 to 515 (Obs/Exp = 1.54 and %GC = 53.50)
CpG island detected in region 317 to 516 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 318 to 517 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 319 to 518 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 320 to 519 (Obs/Exp = 1.58 and %GC = 54.00)
CpG island detected in region 321 to 520 (Obs/Exp = 1.55 and %GC = 54.50)
CpG island detected in region 322 to 521 (Obs/Exp = 1.58 and %GC

80% sisust ei kuvatud. Kogu dokumendi sisu näed kui laed faili alla

100 punkti Autor soovib selle materjali allalaadimise eest saada 100 punkti.

~ 79 lehte Lehekülgede arv dokumendis

2012-11-01 Kuupäev, millal dokument üles laeti

35 laadimist Kokku alla laetud

0 arvamust Teiste kasutajate poolt lisatud kommentaarid

Mumm Õppematerjali autor

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Viienda kodutöö ülesannete vastused aines bioinformaatikaAndmebaasid (KEGG, NCBI, RCSB), järjestuste (SMS, BioEdit) ja struktuuride (SPdbV) analüüs
Andmebaasid , struktuuride analüüs , BIOinformaatika