membraanikomponent phosphatidyl- OH H H inositol H OH O O H2C O C R2 R1 C O CH O CH3 +
Teiseks NGF-aktiveeritud rajaks on rasseoseline MAP kinaaside kaskaad. See rada aktiveerib TFi AP-1. Lisaks sellele TFile i on NGFi radade märklaudadeks ka Egr ja CREB. Egr perekonnaliikmed nagu ka Mek/Erk rada osalevad NGFseoselises neuriitide väljakasvus. CREB perekonnaliikmed on olulised sünpaatiliste neuronite elus hoidmises. Maksarakkudes, hormoon-ajendatud fosfolipaas C aktivatsioon reguleerib glükogeeni lagundamist ning sünteesi inositol-lipiidi kaheharulist signaalrada pidi. Fosfolipaas C genereerib kaht second messenger'i, diatsüülglütserooli (DAG) ning inositol-1,4,5-tri-fosfaat'i (IP3). DAG aktiveerib proteiin kinaas C, mis fosforüülib glükogeeni süntetaasi andes fosforüülitud inaktiivse vormi, seega inhibeerides glükogeeni sünteesi. IP3 põhjustab tsütosoolsete Ca2+ ioonide tõusu, mis aktiveerib glükogeen fosforülaas kinaasi, just nagu lihasrakkudeski, alandades glükogeeni
Escherichia coli K12 MG1655: http://www.kegg.com/dbget-bin/www_bget?eco+b1676 Drosophila melanogaster: http://www.kegg.com/dbget-bin/www_bget?dme+Dmel_CG7069 Homo sapiens: http://www.kegg.com/dbget-bin/www_bget?hsa+5313 c. Leida, milliste teiste metaboolsete radadega antud ensüümid on seotud. Aldolaas: Glycolysis / Gluconeogenesis http://www.kegg.com/dbget-bin/show_pathway?map00010+4.1.2.13 Pentose phosphate pathway http://www.kegg.com/dbget-bin/show_pathway?map00030+4.1.2.13 Inositol metabolism http://www.kegg.com/dbget-bin/show_pathway?map00031+4.1.2.13 Fructose and mannose metabolism http://www.kegg.com/dbget-bin/show_pathway?map00051+4.1.2.13 Carbon fixation http://www.kegg.com/dbget-bin/show_pathway?map00710+4.1.2.13 Püruvaatkinaas: Glycolysis / Gluconeogenesis http://www.kegg.com/dbget-bin/show_pathway?map00010+4.1.2.13 Purine metabolism http://www.kegg.com/dbget-bin/show_pathway?map00230+2.7.1.40 Pyruvate metabolism http://www.kegg.com/dbget-bin/show_pathway
2003; Morzel et al. 2004). Using a model in differentially expressed in samples from which isolated myofibrils were incubated carcasses segregated into high- and low-qual- with μ-calpain under simulated postmortem ity beef grades (based on marbling, lean conditions and protein degradation was mea- color, fat color, maturity, and tenderness) sured by combining MALDI-TOF MS with (Kim et al. 2008). Both HSP27 and inositol SDS-PAGE and 2DE, one study observed 1,4,5-triphosphate (IP3R1), which is involved that desmin, actin, myosin heavy chain, in the intracellular pathways that mediate myosin light chain I, troponin-T, tropomyo- Ca2+ release from intracellular stores sin, thioredoxin, and CapZ were degraded in (Berridge and Lipp 2000), were higher in vitro by μ-calpain (Lametsch et al. 2004). In low-quality beef, and HSP27 was positively
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