109. (a) any two of the following (monomer) not glucose ; contains nitrogen ; contains, sulphur ; AVP ; R ref to branching 2 max (b) amount of glycoprotein varies (in different cells) ; (cells carry out) endocytosis to different extents ; cells have different life spans / example ; no time for polysaccharide to accumulate in short lived cells ; number / role, of lysosomes not same in all cell types ; AVP ; 1 max (c) with Hunter’s syndrome, lysosomes / vesicles, might be larger ; more numerous ; have different shape ; stain differently ; AVP ; e.g. granular cytoplasm 1 max (d) (i) unaffected parents can have an affected child ; ora e.g
present.. CHEDIAK-HIGASHI SYNDROME (CHS) DILUTION (CHEDIAK-HIGASHI SMOKE) This has only been found in Persians and manifested as blue smoke fur with yellow to light- green eyes (normal blue smoke Persians have darker fur and orange/copper eyes). Their eyes reflected red and tended to be sensitive to light. The cats developed cataracts as early as 3 months old. Melanin pigment granules in all tissues, not just the fur, were abnormally in size and shape due to combining with abnormally large lysosomes (part of a cell's digestion mechanism). CHS cats tend to develop kidney lesions, and have impaired vision due to the abnormal pigmentation in the retina. The University of Sydney, Australia's Faculty of Veterinary Science defines CHS as a "rare, lethal disorder" but it better meets the criteria for an "impairing mutation" as its effects can be mitigated with proper care. Affected cats are highly susceptible to infection, due to the abnormally large lysosome in their white blood cells
provided indication of protein breakdown by during aging are thought to be the result of showing that there was an increase in nonco- enzymatic degradation of myofibrillar and 87 88 Chapter 4 cytoskeletal proteins. Thus, the purpose of fied within the lysosome. On the other hand, this chapter is to provide an overview of the lysosomes have fragile membranes that may established theory of enzymatic aging tender- rupture with the decreasing temperature ization and to review recent developments and pH in the muscle during postmortem that contribute to a more complete under- storage. Only cathepsins B, D, H, and L have standing of the underlying mechanisms that been found to degrade the same proteins influence postmortem proteolysis and the as observed during postmortem aging
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