ja Pax7 -> müogeensed regulatoorsed faktorid:bHLH transkriptsioonifaktorid Myf5, Mrf4, MyoD. Dermamüotoom eristub müotoomiks ja dermatoomiks. Differentseeruvad unipotentseteks müoblastideks. Müoblastid liituvad lihastorudeks; Lihastorud organiseeruvad paralleelseteks lihaskiududeks ja need omakorda lihaskimpudeks. Samaaegselt liitumisega lihasrakud differentseeruvad. bHLH faktorid Myogenin, ka MyoD ja Mrf4 -> lihasspetsiifilised geenid/valgud: aktiin, müosiin, tropomyosin, troponin, titin, nebulin, desmin, dystrophin, atsetüülkoliini retseptorid. Osa müoblaste jääb eellasrakkudeks – satelliitrakud. Müoblastid liituvad müotuubideks, mis differentseerivad ja korralduvad lihaskiududeks. Täiskasvanud skeletilihaskiud – hulktuumsed rakud. Sadu tuumasid, lihaskiu pinna all,müofibrillide ja rakumembraani vahel.Sklerotoomi rakud jagunevad eesmiseks-tagumiseks pooleks -> pooled ühinevad -> selgroolüli. Luude moodustumine (osteogenees)
triceps; (contraction) pulls on end of ulna; extensor (muscle)/straightens arm/pulls lower arm down; 2 max 3 max [9] 2+ 45. (calcium ions/Ca ) released from sarcoplasmic reticulum; bind to troponin; troponin changes shape; troponin/tropomyosin, moves; myosin binding site exposed; myosin head binds (to actin); 3 max [3] 46. (Alzheimer’s) 1 reduced uptake of isotope/less positrons emitted/less glucose in brain 2 cells; 3 reduced blood flow; 4 reduced brain activity;
With respect to contraction and rigor The thin filaments (F-actin polymers) are development in postmortem muscle, it is the 1 μm in length and are anchored in the interdigitating thick and thin filaments that Z-line. supply the “machinery” needed for these pro- Two other proteins that are important in cesses and give skeletal muscle cells their muscle contraction and are associated with characteristic appearance (Squire 1981). the thin filament are tropomyosin and tropo- Within the myofibril, the less dense I-band is nin. Tropomyosin is the second-most abun- made up primarily of thin filaments, while dant protein in the thin filament and makes the A-band is made up of thick filaments and up about 7% of the total myofibrillar protein. some overlapping thin filaments (Goll et al. Tropomyosin is made up of two polypeptide 1984). The backbone of the thin filaments is chains (alpha and beta) The alpha chain has
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