elundkonda haarav) ülitundlikkusreaktsioon. Kujuneb mõne minutiga, vajab kohest esmaabi (adrenaliini süst- kitsendab veresooni, avab hingamisteed, kõrgendab vererõhku, alandab sügelust). 2. Lokaalne: allergiline nohu, astma, toiduallergia A type I hypersensitive reaction is mediated by IgE antibodies, whose Fc region binds to receptors on mast cells or blood basophils. Crosslinkage of the fixed IgE by allergen leads to mast cell or basophil degranulation with release of pharmacologically active mediators. The principal effects of these mediators are smooth-muscle contraction and vasodilation. Tüüp II: tekivad enamasti autoantikehade mõjust kudedele, harvem on need tingitud mikroobidevastastest antikehadest. Koekahjustus tekib seeläbi, et antikehad (IgG1, IgG3) aktiveerivad kudedes leukotsüüte, seostudes nende pinnal olevate vastavate Fc- retseptoritega, võivad aktiveerida ka komplemendisüsteemi klassikalise tee kaudu. Antikehade
pyridinols, ionophores Carbamates and pyrethroids Esters of carbamic acid, type 1 and 2 pyrethroids Sedatives Butyrophenones, promazines, β-blocker carazolol Non-steroidal anti-inflammatory drugs Salicylates, pyrazolones, nicotinic acids, phenamates, arylpropionic acids, pyrrolizines Other pharmacologically active substances Dexamethasone Group B: Contaminants 3 Environmental contaminants Organochlorine compounds PCBs, compounds derived from aromatic, cyclodiene or terpenic hydrocarbons Organophosphorous compounds Malathion, phorate Chemical elements Heavy metals Mycotoxins Aflatoxins, deoxynivalenol, zearalenone Dyes Others
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