Acyclovir - toimemehhanism § Atsükliline guanosiini derivaat § Fosforüülitakse raku sees viirusliku tümidiin-kinaasi poolt § Di-ja tri-fosforüülimine premeesraku ensüümide poolt § Pärsib viirusliku DNA sünteesi: § konkureerib dGTP-ga viirusliku DNA polümeraasi pärast § viiruse DNA ahelasse sattudes lõppeb nukleiinhappe süntees. Antiretroviiruslikud ravimid (HIV ravimid) § Nukleosiidsed pöördtranskriptaasi inhibiitorid (Nucleoside Reverse Transcriptase Inhibitors -NRTI) § Mittenukleosiidsed pöördtanskriptaasi inhibiitorid (Nonnucleoside Reverse Transcriptase Inhibitors - NNRTI) § Proteaasi inhibiitorid § Fusiooni inhibiitorid § Integraasi inhibiitorid.
harbors a second putative arginine deaminase sucrose) are usually included in the industrial pathway, containing two peptydil-arginine manufacture of fermented meat products, deaminases, enzymes that can contribute to though in Spain, chorizo is traditionally man- the metabolism of arginine (Chaillou et al. ufactured with little or no added sugar. 206 Chapter 10 During fermentation and ripening, LAB inosine hydrolase, and nucleoside phosphor- convert glucose (their primary energy source) ylase, all of which enable the release of a to lactic acid, which is the main component ribose moiety from nucleoside (adenosine responsible for the pH decrease. This acidifi- and inosine) and its subsequent metabolism cation has a preservative effect, due to inhibi- (Chaillou et al. 2005). Moreover, the pres- tion of pathogenic and spoilage bacteria with ence of methylglyoxal synthase, a novel
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