· Teratogenicity Toxic starting from 21 mg aniline/kg bw/day. c) Carcinogenicity Aniline is currently classified as carcinogenic, category 3 and labelled with R40 "limitedevidence of a carcinogenic effect". Animal studies have shown an increase in tumors of the spleen in rats exposed to aniline hydrochloride. EPA calculated an oral cancer slope factor of 5.7 x 10-3 (mg/kg/d) -1 and an oral unit risk estimate of 1.6 × 10- 7 (µg/L)-1. d) Genotoxicity and mutagenicity Aniline did not induce unscheduled DNA repair in primary human or rat hepatocytes. In mice, aniline induced micronuclei in several studies, but only at very high dose levels in the toxic range. Negative results have been found in the analysis of sperm head anomalies and equivocal results in the dominant lethal test. e) Other toxic effects, e.g. immunotoxicity and local toxicity - No information available. f) Ecotoxicity
products. in charge of issuing a list of primary products Some alternative processes have been allowed for use as such in/or on food and/or designed to reduce the contamination of the for the production of derived smoke flavor- smoked meat products with hazardous com- ings. Studies on subchronic toxicity and pounds. Some of these strategies that can genotoxicity must be performed to evaluate reduce significantly the PAH content in the potential toxicological effects of the smoked meat products consist of the filtration primary products used for smoke flavoring. of particles, the use of cooling traps, lower Regulation 627/2006 implements temperatures, and/or reducing the duration of Regulation 2065/2003 regarding quality the process. Alternatively, liquid smoke can criteria for validated analytical methods for
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