Makroliidide mõju kasvava peptiidi liikumisele väljumistunnelis Makroliidid - laktoonrõngas, mille küljes on erinevad suhkrujäägid. Ribosoomi suure subühiku PTC asub peptiidi kanali juures. Makroliidid seonduvad kanalisse PTC ette ning sünteesitud valk ei suuda väljuda. tRNA ei suuda seonduda korralikult ribosoomile ning kukub välja. Translatsioon peatub. Kloramfenikool ja peptidüültransferaasse reaktsiooni inhibeerimine Chloramphenicol prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation. While chloramphenicol and the macrolide class of antibiotics both interact with ribosomes, chloramphenicol is not a macrolide. It directly interferes with substrate binding, whereas
multidisciplinary intensive care unit. Critical Care genes. The absence of genes coding for 8:42–47. staphylococcal enterotoxins or enterotoxin- Ahn, C., D. Collins-Thompson, C. Duncan, and M. like superantigens is a qualification required Stiles. 1992. Mobilization and location of the genetic determinant of chloramphenicol resistance from for CNS strains selected for use as starter Lactobacillus plantarum caTC2R. Plasmid 27: cultures. 169–176. Ammor, M., M. Gueimonde, M. Danielsen, M. Zagorec, A. van Hoek, C. de Los Reyes-Gavilán, B. Mayo, and Conclusion A. Margolles. 2008. Two different tetracycline
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