COMMONused tNSAID og of diclofenac. ADVERSE in Europe. EFFECTS The selective inhibitor of COX-2 Side effects occur in 2540% of patients who take tolmetin, and 510% dis drug. Gastrointestinal side effects are the most common (15%) and gastric u observed. CNS side effects similar to those seen with indomethacin and aspirin less common and less severe. Ketorolac Ketorolac is a potent analgesic but only a moderately effective anti-inflamma of the few NSAIDs approved for parenteral administration. AL PROPERTIES sic, antipyretic, and anti-inflammatory activities. Diclofenac appears to oncentrations of free AA in leukocytes, perhaps by altering its release or PHARMACOLOGICAL PROPERTIES Para-aminofenoolid Selektiivsed COX-2 inhibiitorid e koksiibid Diarüülasendusega furanoonid rofekoksiib (ei turustata) Diarüülasendusega pürasoolid - tselekoksiib
võimalusel PATSIENDI POOLT KONTROLLITUD ANALGEESIA (PCA) Patsiendi poolt kontrollitud analgeesia võttis kasutusele 1968 a. Philip H. Sechzer (13.09.1914 26.09.2004) Esimest korda kirjeldas 1971 a. (1, 2) 1991 a. PCA postoperatiivse anlgeesia "kuldne standard" (3) Patsient iseseisvalt manustab endale valuvaigist, kasutades selleks programmeeritud pumpa (tavaliselt - automaatsüstalt) 1.Sechzer PH. Studies in pain with the analgesic-demand system. Anesth Analg 1971;50:1-10. Loeser, John David; Bonica, John J.; Butler, Stephen H.; 2.Chapman, C. Richard (2001), Bonica's Management of Pain (3 ed.), Philadelphia, PA: Lippincott Williams & Wilkins, p. 772. 3. De Kock M., Scholtes J.L. // Acta Anaesthesiol. Belg. - 1991. -Vol.142, N2. - P. 85-91. BALANSSEERITUD (MULTIMODAALNE) VALURAVI ESRA and Pain Therapy (2005) European Society of Regional Anaesthesia and Pain Therapy vähemalt 2
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