Liha töötlemine
Evidence has been accumulating that cal- (Foucrier et al. 2001) of skeletal muscle.
pains are necessary to initiate the degradation Control of indiscriminate proteolysis appears
of myofibrillar proteins by releasing them to be regulated by two methods. The MCP
from the surface of the myofibril and making preferentially degrades polypeptides that
them available for subsequent degradation. have been ubiquitinated and secondly by
Given that calpains cleave proteins at a physical size limitation; that is, only poly-
limited number of sites and produce large peptides that can pass through the narrow
polypeptide fragments rather than small pep- 10–13Å opening to the central core of the
tides or amino acids, it is clear that other barrel are easily degraded into 6–12 amino
proteases may be involved in the bulk degra- acid fragments in a single pass (Attaix et al.
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