"subendothelial" - 1 õppematerjal

Süsteemne erütematoosne luupus

paremini neerukahjustusega · Hüpokomplementeemia (70-90%) · Ainult biopsia võimaldab kindlaks määrata luupusnefriidi morfoloogilisi vorme  Luupusnefriidi klassifikatsioon CLASS I Minimal mesangial LN: · Normal glomeruli by LM but mesangial immune deposits by IF CLASS II Mesangial Proliferative LN: · Mesangial proliferation and/or expansion by LM with mesangial immune deposits by IF and/or EM without endocapillary proliferation CLASS III Focal LN: · segmental or global; focal subendothelial immune complexes, +/- mesangial alterations CLASS IV Diffuse LN: · diffuse subendothelial immune complexes, +/- mesangialnalterations CLASS V Membranous LN: · global or segmental subepithelial immune deposits, +/- mesangial alterations · may show advanced sclerosis CLASS VI Advanced sclerosing LN: · Sclerosis affecting >90% of glomeruli globally without residual  Ravi · Klass I ja II ­ väga hea prognoos, ei vaja ravi