Cats
melanosomes. There were also complex giant granules consisting of both melanosomal and
lysosomal components. Inappropriate fusion of cytoplasmic granules appears to be the most
likely mechanism for formation of the giant granules. Fusion of premelanosomes with
lysosomes and resultant destruction of the premelanosomes probably is a major cause of the
ocular hypopigmentation of Chediak-Higashi syndrome."
Hargis AM, Prieur DJ. Animal model: renal lesions in cats with Chediak-Higashi-Steinbrinck
syndrome. Am J Med Genet. 1987 Jan;26(1):169-79. "In this study designed to characterize
the renal lesions in cats with the autosomal recessive Chediak-Higashi-Steinbrinck syndrome
(CHS), the renal tubular epithelial cells of CHS cats were examined by light microscopy. The
lesions observed were similar to those in the renal epithelial cells of other species with CHS
and were consistent with those reported previously in other tissues of CHS cats."
Kramer JW, Davis WC, Prieur DJ
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