Synthesis of Ibuprofen
6 samples per instrument.
To eliminate systematic errors randomization is applied for the
samples. The experiment is expected to be completed in a day
by one person
HPLC S4 UV-VIS S1 UV-VIS S3 HPLC S2 HPLC S3 HPLC S5
UV-VIS S5 HPLC S6 HPLC S1 UV-VIS S4 UV-VIS S2 UV-VIS S6
For comparing two means, t-test [1] will be performed. Before making t-test,
F-test has to be made to make sure if the means have equivalent precisions.
Depending of the outcome of F-test following t-test will be made
Optimization
Another synthesis procedure e.g. Boots' synthesis
procedure.
Increase the speed of forming Grignard formation,
which minimizes coupling. For this use
mechanically activated magnesium.
Decrease the degree of coupling by lowering
temperature.
To shorten the synthesis, it is possible to go from
starting ketone directly to the chloride without
isolating alcohol.
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