Infectious bovine keratoconjunctivitis 2019
resistance and it is considerable defence mechanism for being washed away or destroyed by
bovine tear secretions. One of the main defence factors in the bovine tear is lysozyme. Studies
have shown that lysozyme have ability to reduce the production of biofilms, but do not have
the capacity to destroy the preformed biofilms (Ely et al., 2017). In addition to the tear film
there are other protection factors such as epithelium, phagocytic cells, local secretory
antibody. Cornea and conjunctiva epithelial surface are an effective barrier against bacteria
invasion. Due to the regeneration of epithelial cells take place every 5-7 days, therefore
microorganism must stick to cells in order to infect them, and this continuous turnover of
epithelial cells slows down bacterial adhesion (Postma et al., 2007). In conclusion tear films
are likely one of the most essential mechanisms to avoid fixation and colonization by
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