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"peroxynitrite" - 1 õppematerjal

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1997; Carlin It does have the ability to combine with other et al. 2006). biomolecules that also have physiological Oxidation does occur early in postmortem importance. meat, and it does influence proteolysis (Harris One example of this is its ability to et al. 2001; Rowe et al. 2004b). Rowe et al. combine with superoxide to form the highly (2004) showed that there was a significant oxidizing molecule peroxynitrite. Proteins increase in proteolysis of troponin-T in steaks are important biological targets of peroxyni- from alpha-tocopherol-fed steers after 2 days trite, particularly proteins containing cyste- of postmortem aging compared with steers ine, motioning, and/or tryptophan (Radi et al. fed a conventional feedlot diet. This indicates 2000). Several enzymes are known to be that very low levels of oxidation can influ- inactivated by peroxynitrite. Among these is

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