Valkude ruumiline struktuur
Hemoglobiini ahel Oligomeerse valgu molekuli assotsieerumine
mikrotorukeseks
Valkude ruumiline struktuur
regulaarne või irregulaarne?
Primaarstruktuurid tohutult varieeruvad
1934 pepsiini kristallidelt difraktsioon
1958 müoglobiini struktuur (Kendrew)
1965 lüsotsüüm
raeguseks on teada ca 10000 valgu struktuur
"Perhaps the most remarkable features of the
molecule are its complexity and its lack of
symmetry. The arrangement seems to be almost
totally lacking in the kind of regularities which
one instinctively anticipates, and it is more
complicated than has been predicted by any
theory."
John Kendrew kommenteerides esimest
globulaarse valgu kristallstruktuuri, Cambridge
University, 1958