Cats
months old. Melanin pigment granules in all tissues, not just the fur, were abnormally in size
and shape due to combining with abnormally large lysosomes (part of a cell's digestion
mechanism). CHS cats tend to develop kidney lesions, and have impaired vision due to the
abnormal pigmentation in the retina. The University of Sydney, Australia's Faculty of
Veterinary Science defines CHS as a "rare, lethal disorder" but it better meets the criteria for
an "impairing mutation" as its effects can be mitigated with proper care. Affected cats are
highly susceptible to infection, due to the abnormally large lysosome in their white blood
cells. Bacterial infections occur repeatedly because the white blood cells cannot respond
normally to infection; antibiotic treatment is required to combat infection. Prolonged bleeding
tends to occur because of abnormal blood platelets delaying clotting. In the laboratory, CHS
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