Aniliini riskianalüüs (eng)
· General toxicity after repeated administration
The main endpoint of aniline after repeated dosing is toxicity to the haematopoietic
system with erythrotoxicity, methaemoglobinaemia, haemolytic anaemia and
formation of Heinz bodies, with corresponding changes of the spleen, the bone
marrow, the kidneys and the liver. The damaged red blood cells are scavenged
predominantly in the red pulp of the spleen, followed by increased haemosiderin
accumulation. Experience from humans after repeated oral intake gives indications of
haematotoxicity at dosages from 0.4 mg/kg bw/day.
b) Reproduction toxity
· Developmental toxicity
The critical exposure level for potential developmental toxicity has been determined
to be 150 mg/person/day or 15 mg/m3.
· Reproduction toxicity
No effects in any of the organs of the reproductive system of either males or females
annaabi.ee 
