Aniliini riskianalüüs (eng)
of aniline in adult human is about 0.2 mg/kg bodyweight. In animal experiments the
acute toxicity of aniline shows significant species differences, with cats being much
more sensitive than conventional laboratory animals.
· General toxicity after repeated administration
The main endpoint of aniline after repeated dosing is toxicity to the haematopoietic
system with erythrotoxicity, methaemoglobinaemia, haemolytic anaemia and
formation of Heinz bodies, with corresponding changes of the spleen, the bone
marrow, the kidneys and the liver. The damaged red blood cells are scavenged
predominantly in the red pulp of the spleen, followed by increased haemosiderin
accumulation. Experience from humans after repeated oral intake gives indications of
haematotoxicity at dosages from 0.4 mg/kg bw/day.
b) Reproduction toxity
· Developmental toxicity
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