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"haematotoxicity" - 1 õppematerjal

Aniliini riskianalüüs-eng
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Aniliini riskianalüüs (eng)

system with erythrotoxicity, methaemoglobinaemia, haemolytic anaemia and formation of Heinz bodies, with corresponding changes of the spleen, the bone marrow, the kidneys and the liver. The damaged red blood cells are scavenged predominantly in the red pulp of the spleen, followed by increased haemosiderin accumulation. Experience from humans after repeated oral intake gives indications of haematotoxicity at dosages from 0.4 mg/kg bw/day. b) Reproduction toxity · Developmental toxicity The critical exposure level for potential developmental toxicity has been determined to be 150 mg/person/day or 15 mg/m3. · Reproduction toxicity No effects in any of the organs of the reproductive system of either males or females (for mice). No information is available on the reproductive effects of aniline in humans. · Teratogenicity

Meditsiin → Riski- ja ohuõpetus
38 allalaadimist


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