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"foucrier" - 1 õppematerjal

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and peptidylglutamyl peptide hydrolase (PGPH). The MCP proteasome enzymes have optimal pH activity at pH 7.0–8.0, and Proteasomes the proteasome is found in the sarcoplasm Evidence has been accumulating that cal- (Foucrier et al. 2001) of skeletal muscle. pains are necessary to initiate the degradation Control of indiscriminate proteolysis appears of myofibrillar proteins by releasing them to be regulated by two methods. The MCP from the surface of the myofibril and making preferentially degrades polypeptides that them available for subsequent degradation. have been ubiquitinated and secondly by Given that calpains cleave proteins at a physical size limitation; that is, only poly-

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