MyoD. Dermamüotoom eristub müotoomiks ja dermatoomiks. Differentseeruvad unipotentseteks müoblastideks. Müoblastid liituvad lihastorudeks; Lihastorud organiseeruvad paralleelseteks lihaskiududeks ja need omakorda lihaskimpudeks. Samaaegselt liitumisega lihasrakud differentseeruvad. bHLH faktorid Myogenin, ka MyoD ja Mrf4 -> lihasspetsiifilised geenid/valgud: aktiin, müosiin, tropomyosin, troponin, titin, nebulin, desmin, dystrophin, atsetüülkoliini retseptorid. Osa müoblaste jääb eellasrakkudeks – satelliitrakud. Müoblastid liituvad müotuubideks, mis differentseerivad ja korralduvad lihaskiududeks. Täiskasvanud skeletilihaskiud – hulktuumsed rakud. Sadu tuumasid, lihaskiu pinna all,müofibrillide ja rakumembraani vahel.Sklerotoomi rakud jagunevad eesmiseks-tagumiseks pooleks -> pooled ühinevad -> selgroolüli. Luude moodustumine (osteogenees). Jäsemete luud – külgplaadi mesodermi (lateral
would lead to shortening and subsequent responsible for attaching the myofibrils to the lowering of the volume of the I-band region sarcolemma. Proteins that make up or are in myofibril. Loss of volume in this myofi- associated with the intermediate filaments brillar region (where much water may reside), and costameres include (among others) combined with the pH-induced lateral shrink- desmin, filamin, synemin, dystrophin, talin, age of the myofibril, could lead to expulsion and vinculin (Greaser 1991). If costameric of water from the myofibrillar structure linkages remain intact during the conversion into the extramyofibrillar spaces within the of muscle to meat, shrinkage of the myofi- muscle cell (Bendall and Swatland 1988). In brils as the muscle goes into rigor would be fact, recent NMR studies support this hypoth- transmitted to the entire cell via these pro-
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