"deoxyhaemoglobin" - 1 õppematerjal

Exercise Physiology - lecture 4 Blood, gas exchange, transport

· Assuming a total plasma V of 3-5 L, only ~ 9-15 ml O2 can be carried in a dissolved state. · Resting tissues require > 250ml O2 per min. 2. In combination with haemoglobin within the RBC (greater than 98%) · Haemoglobin within each of the 4-6 billion RBC allows blood to transport ~ 70 times more O2  Haemoglobin saturation 1 molecules haemoglobin = 4 molecules of O2 O2 + haemoglobin = oxyhaemoglobin Haemoglobin ­ oxygen = deoxyhaemoglobin Binding of O2 to Hb depends on PO2 in blood and the bonding strength (affinity) between Hb and O2. O2-hb disassociation curve Oxygen-haemoglobin Dissociation curve High drop in PO2 associated with only slight changes in O2 saturation. As PO2 of blood increases saturation increases. As PO2 of blood decreases affinity between O2 and Hb