dation of sarcomeric structures (Goll et al. 1998, 2001; Glickman and Cienchanover 2003). For the subsequent breakdown of 2002). It is likely that another protease, cal- myofibrillar proteins, once calpains have pains for example, acts in concert or synergy released them from the sarcomere, the main to release proteins from the myofibrillar candidate is the proteasome (Attaix et al. assembly in order to make large proteins 1998, 2001; Delbarre-Ladrat et al. 2006; available for degradation into amino acids by Yamamoto et al. 2009; Geesink and Veiseth the MCP (Hasselgren 1999; Allen and Goll 2009). 2003). The MCP plays a major role in degrad- The proteasome, or multicatalytic protein- ing sarcoplasmic proteins and myofibrillar ase complex (MCP), is a multisubunit prote- fragments; however, there is insufficient evi-
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