Molekulaarbioloogia praksi kontrolltöö vastused
the notochord the floorplate, and the neural ectoderm
itself, they bind to cell surface receptors, many which are protein kinases.
Retinoic acid (RA) may act as a regulator of differentiation at various stages of vertebrate
embryogenesis. In particular, the results of exogeneous RA treatment have implicated RA
in antero-posterior patterning both along the body axis and in developing Limb bud. A
variety of abnormalities, including Neural tube defects, craniofacial abnormalities, and
limb defects, have been reported after treatment of pregnant mammals with RA. The
recent discovery that RA interacts with nuclear Receptors related to the steroid and
thyroid hormone receptors, a family of proteins that function as ligand-dependent
transcription factors, suggests that the morphogenetic functions of RA may result at least
in part, from activation of developmentally regulated genes by RA receptor (RAR)
complexes
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