Immunoloogia eksami kordamisküsimused
antikehade ja komplemendi abil.
28. Kuidas kujuneb välja bakteriaalne septiline sokk? Mis on septilise soki
kliinilised tunnused?
1. Bacterial toxins or LPS bind to TLRs on monocytes, systemically.
2. This results in the production of TNF, IL-1, and other pro-inflammatory
cytokines. Fever.
3. Neutrophils are recruited to the blood stream
4. Endothelial cells respond to the TNF, IL-1, lowing blood pressure and
resulting in the expression of chemokines by the endothelial cells.
5. Activation and egress of neutrophils from the vessels leads to an
oxidative response and more vascular leakage, lowering blood pressure
even more.
6. The kinin proteolytic cascade is induced, resulting in production of
bradykinin and increased vascular permeability.
7. The coagulation cascade is initiated. Disseminated intravascular clotting
occludes small vessels, reducing perfusion of all major organs. Eventually,
this contributes to organ failure.
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annaabi.ee 
