"Synthesis of Ibuprofen" - 1 õppematerjal

Synthesis of Ibuprofen

Synthesis of Ibuprofen Ingrid Puusta  Historical/commercial significance Non-steroidal anti-inflammatory drug For reducing pain, inflammation and fever Patented in 1961 by the research arm of Boots company and led by Stewart Adams Aim was to find safer product instead of Aspirin Industrial production follows Boots ` synthesis procedure  Ibuprofen in body It acts on compounds called prostaglandins: Physiologically active lipid compounds having diverse hormone Found in almost every tissue in human They are derived enzymatically from fatty acids They bring out inflammatory response Ibuprofen's action as a painkiller and fever-reducing compound is due to its ability to inhibit the synthesis of prostaglandins It does this by interfering with the action of an enzyme called cyclooxygenase which catalyzes the conversion of a compound called arachidonic acid into prostaglandins 4 step Ibuprofen...