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"toxicokinetics" - 1 õppematerjal

Formaldehyde
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Formaldehyde

CAS number: 50-00-0 IUPAC name: Methanal Structure formula: HCHO Physical characteristics: Colorless gas (normal.), Odor: Pungent, suffocating odor; highly irritating , Density: 0.815 g/mL (8153 g/cm³ (­20°C) ) Molar mass 30.03 g mol-1 s, Solubility: Freshwater at 20°C Very soluble; up to 55% Partition coefficients: Log Pow=0.35 (25°C), Log Koc= 1.567 Melting and boiling point: Tm=-92°C,Tb=-19°C Autoignition temperature: 300 °C Henry's law constant at 25°C H: 0,034 Pa*m3/mol TOXICOKINETICS The toxicokinetics of formaldehyde after inhalation, oral, or dermal exposure has been reported in several species by many investigators. The toxicokinetics in all of the animals studied is similar across species lines. Formaldehyde is an essential metabolic intermediate in all cells. It is produced during the normal metabolism of serine, glycine, methionine, and choline and also by the demethylation of N-, S-, and O-methyl compounds. After oxidation of formaldehyde to formate, the

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