"matsuura" - 1 õppematerjal

Liha töötlemine

1992). at approximately 2,400 kDa (Kurzban and Degradation of nebulin postmortem could Wang 1988, 1987; Huff-Lonergan et al. weaken the thin filament linkages at the 1995). Another titin degradation product Z-line, and/or of the thin filaments in the that has been observed by SDS-PAGE an- nearby I-band regions (Taylor et al. 1995), alysis migrates at approximately 1,200 kDa and thereby weaken the structure of the (Matsuura et al. 1991; Huff-Lonergan et al. muscle cell. Nebulin has also been shown to 1995). This latter polypeptide has been be capable of linking actin and myosin (Root shown to contain the portion of titin that and Wang 1994a, b). It has been hypothe- extends from the Z-line to near the N2 line sized that nebulin may also have a regulatory in the I-band (Kimura et al. 1992), although function in skeletal muscle contraction (Root