Phosphate Binders: Your Questions Answered What's the deal with phosphate in kidney disease anyway? Phosphate and calcium are both minerals that are essential in maintaining a healthy body. Together, they help build strong, healthy bones and teeth, and also play a role in regular cell and nerve function. Through a delicate process called homeostasis, the body keeps both phosphate and calcium at healthy levels. Both the kidneys and the parathyroid glands play vital roles. First, the kidneys, which activate vitamin D, control the amount of phosphate that is absorbed and excreted from the foods you eat. Second, a hormone called parathyroid hormone (PTH) regulates phosphate by increasing or decreasing the blood's phosphate concentration. A normal blood phosphate level in adults is 3-4.5 mg/dL and a normal PTH is 10-55 pg/mL. However, in kidney disease and kidney failure, the body is not able to keep the levels of phosphate at healthy level...
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